| Assignment | School Structure |
| Aerospace | High School, Grades 9-12 |
| Anatomy | High School, Grades 9-12 |
| Anatomy and Physiology | High School, Grades 9-12 |
| Ancient and Medieval History | High School, Grades 9-12 |
| Ancient Civilizations | High School, Grades 9-12 |
| Anthropology | High School, Grades 9-12 |
| AP Biology | High School, Grades 9-12 |
| AP Chemistry | High School, Grades 9-12 |
| AP Comparative Government and Politics | High School, Grades 9-12 |
| AP Environmental Science | High School, Grades 9-12 |
| AP European History | High School, Grades 9-12 |
| AP Government | High School, Grades 9-12 |
| AP Human Geography | High School, Grades 9-12 |
| AP Physics AB | High School, Grades 9-12 |
| AP Physics C | High School, Grades 9-12 |
| AP Psychology | High School, Grades 9-12 |
| AP U.S. History | High School, Grades 9-12 |
| AP US Government & Politics | High School, Grades 9-12 |
| AP World History | High School, Grades 9-12 |
| Applied Biology/Chemistry | High School, Grades 9-12 |
| Astronomy | High School, Grades 9-12 |
| Astronomy / Meteorology | High School, Grades 9-12 |
| Biology | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| Biology Advanced Studies | High School, Grades 9-12 |
| Botany | High School, Grades 9-12 |
| Chemistry | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| Chemistry Advanced Studies | High School, Grades 9-12 |
| Civics | High School, Grades 9-12 |
| Comparative Government | High School, Grades 9-12 |
| Conceptual Biology | High School, Grades 9-12 |
| Conceptual Chemistry | High School, Grades 9-12 |
| Conceptual Physics | High School, Grades 9-12 |
| Consumer Law | High School, Grades 9-12 |
| Contemporary U.S. Issues | High School, Grades 9-12 |
| Contemporary World Issues | High School, Grades 9-12 |
| Early US History | High School, Grades 9-12 |
| Earth and Space Science | High School, Grades 9-12 |
| Earth Science | High School, Grades 9-12 |
| Earth Science | Middle School/Junior High, Grades 5-8 |
| Environmental Science | High School, Grades 9-12 |
| General Science | Middle School/Junior High, Grades 5-8 |
| General Science, Grade 5 | Elementary, Grades PK-8 |
| General Science, Grade 6 | Elementary, Grades PK-8 |
| General Science, Grade 7 | Elementary, Grades PK-8 |
| General Science, Grade 8 | Elementary, Grades PK-8 |
| Genetics | High School, Grades 9-12 |
| Geology | High School, Grades 9-12 |
| Humanities | High School, Grades 9-12 |
| Integrated Science | Middle School/Junior High, Grades 5-8 |
| Integrated Science | High School, Grades 9-12 |
| International Relations | High School, Grades 9-12 |
| Issues of Western Humanities | High School, Grades 9-12 |
| Law Studies | High School, Grades 9-12 |
| Legal System | High School, Grades 9-12 |
| Life Science | Middle School/Junior High, Grades 5-8 |
| Marine Science | High School, Grades 9-12 |
| Medieval European History | High School, Grades 9-12 |
| Meteorology | High School, Grades 9-12 |
| Microbiology | High School, Grades 9-12 |
| Modern European History | High School, Grades 9-12 |
| Modern Intellectual History | High School, Grades 9-12 |
| Modern US History | High School, Grades 9-12 |
| Modern World History | High School, Grades 9-12 |
| Native American Studies | High School, Grades 9-12 |
| Organic Chemistry | High School, Grades 9-12 |
| Philosophy | High School, Grades 9-12 |
| Physical Chemistry | High School, Grades 9-12 |
| Physical Geography | High School, Grades 9-12 |
| Physical Science | Middle School/Junior High, Grades 5-8 |
| Physical Science | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| Physics | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| Physics - Advanced Studies | High School, Grades 9-12 |
| Physiology | High School, Grades 9-12 |
| Political Science | High School, Grades 9-12 |
| Principles of Democracy | High School, Grades 9-12 |
| Profound Events in History | High School, Grades 9-12 |
| Psychology | High School, Grades 9-12 |
| Science, Technology, and Society | High School, Grades 9-12 |
| Scientific Research and Design | High School, Grades 9-12 |
| Social Problems/Relations | High School, Grades 9-12 |
| Social Science | High School, Grades 9-12 |
| Social Science Research | High School, Grades 9-12 |
| Sociology | High School, Grades 9-12 |
| South Dakota History | High School, Grades 9-12 |
| State and Local Government | High School, Grades 9-12 |
| Tribal Government | High School, Grades 9-12 |
| United States and World Affairs | High School, Grades 9-12 |
| US Ethnic Studies | High School, Grades 9-12 |
| US Gender Studies | High School, Grades 9-12 |
| US Government - Comprehensive | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| US History - Comprehensive | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| Western Civilization | High School, Grades 9-12 |
| World Area Studies | High School, Grades 9-12 |
| World Geography | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| World History - Overview | High School, Grades 9-12 and MS/JH, Grades 5-8 |
| World People Studies | High School, Grades 9-12 |
| Zoology | High School, Grades 9-12 |